Originally Posted by Cookie2
Acetaminiphine (Tylenol) is metabolized by the liver. Never mix it with alcohol! Naproxin (Aleve) is mostly metabolized by the kidneys. Drink plenty of water.
You're supposed to take them 2 hours apart. However, since you're not making a habit of it or taking large doses (right?!) your body will probably be okay.
Naproxin never does anything for me. I can't stand the stuff because once you take it you can't take ibuprofen or asprin for hours on end.
This is what I would have said too. Just be careful not to take ibuprofen and aleve together, as they are both metabolized by the kidneys. I would also be careful to take with food, as large amounts of drugs can be hard on the gut (though tylenol isn't as bad as ibuprofen).